|
|
acetyl-CoA + cortisol <=> cortisol_21-acetate + CoA
|
2.3.1.27
cortisol O-acetyltransferase
|
–
|
|
| |
BRENDA:
BR44026
KEGG:
R02837
MetaCyc:
CORTISOL-O-ACETYLTRANSFERASE-RXN
|
|
|
|
3''-phosphoadenylyl-sulfate + cortisol <=> adenosine_3,5''-bisphosphate + Cortisol_21-sulfate + H+
|
2.8.2.15
steroid sulfotransferase
2.8.2.18
cortisol sulfotransferase
2.8.2.2
alcohol sulfotransferase
|
–
–
–
|
|
| |
BRENDA:
BR48111
KEGG:
R02839
MetaCyc:
CORTISOL-SULFOTRANSFERASE-RXN
|
|
|
|
11-deoxycortisol + reduced_adrenodoxin + O2 + H+ <=> H2O + cortisol + oxidized_ferredoxin
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
M
|
| |
BRENDA:
BS186773;
BS425303
MetaCyc:
RXN66-357
|
|
|
|
cortisol + NADH + H+ <=> 20alpha-dihydrocortisol + NAD+
|
1.1.1
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
|
–
–
|
|
| |
BRENDA:
BS187282
MetaCyc:
RXN-15357
|
|
|
|
cortisol + NADP+ <=> cortisone + NADPH + H+
|
1.1.1
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.B40
|
–
–
–
|
K
|
| |
BRENDA:
BS370906
KEGG:
R02836
MetaCyc:
RXN-12085
SABIO-RK:
2701
|
|
|
|
cortisol + NAD+ <=> cortisone + NADH
|
1.1.1
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.B40
|
–
–
–
–
|
K
|
| |
BRENDA:
BS370905
KEGG:
R02834
SABIO-RK:
2700
|
|
|
|
cortisol + NADPH <=> 11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
K
|
| |
BRENDA:
BS388394
KEGG:
R02841
SABIO-RK:
2706
|
|
|
|
21-deoxycortisol + reduced_flavodoxin + O2 <=> cortisol + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
K
|
| |
KEGG:
R02838
|
|
|
|
cortisol + H+ + NADH <=> 11beta,17alpha,21-Trihydroxypregnenolone + NAD+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
K
|
| |
KEGG:
R02840
|
|
|
|
11-deoxycortisol + 2 reduced_ferredoxin + O2 + 2 H+ <=> cortisol + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
K
|
| |
KEGG:
R02843
|
|
|
|
cortisol <=> 11beta-hydroxyandrost-4-ene-3,17-dione
|
not assigned
|
–
|
K
|
| |
KEGG:
R08995
|
|
|
|
cortisol + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ + O2 <=> 9alpha-hydroxy-11beta-hydrocortisone + 2 oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
|
| |
BRENDA:
BS418204
|
|
|
|
11-deoxycortisol + adrenal_ferredoxin + H2O <=> cortisol + reduced_ferredoxin + O2
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS394618
|
|
|
|
cortisol + 2,6-dichlorophenolindophenol <=> Prednisolone + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
| |
BRENDA:
BS395310
|
|
|
|
cortisol + reduced_ferredoxin + O2 <=> cortisone + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS186785
|
|
|
|
11,17-dihydroxyprogesterone + NADH + O2 <=> cortisol + NAD+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
| |
BRENDA:
BS186798
|
|
|
|
cortisol + NADPH <=> 11beta,17alpha,21-trihydroxypregnan-3,20-dione + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
|
| |
BRENDA:
BS258421
|
|
|
|
cortisol + NADPH <=> 3beta,11beta,17alpha,21-tetrahydroxy-4-pregnen-20-one + NADP+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS257057
|
|
|
|
11-deoxycortisol + NADPH + O2 <=> cortisol + NADP+ + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS387040
|
|
|
|
3''-phosphoadenylylsulfate + cortisol <=> adenosine_3'',5''-bisphosphate + hydrocortisone_sulfate
|
2.8.2.2
alcohol sulfotransferase
|
–
|
|
| |
BRENDA:
BS360324
|
|
|
|
11-deoxycortisol + reduced_ferredoxin + O2 <=> cortisol + Ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS386036
|
|
|
|
11-deoxycortisol + reduced_ferredoxin + O2 <=> cortisol + adrenal_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS386037
|
|
|
|
cortisol + acceptor <=> Prednisolone + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
| |
BRENDA:
BS258862
|
|
